SOCS5 SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. Note: This description may include information from UniProtKB.
Protein type: Inhibitor
Chromosomal Location of Human Ortholog: 17|17 E4
Cellular Component:  cytoplasm; phosphatidylinositol 3-kinase complex
Molecular Function:  1-phosphatidylinositol-3-kinase regulator activity; epidermal growth factor receptor binding; kinase inhibitor activity; protein binding; receptor tyrosine kinase binding
Biological Process:  cellular response to low-density lipoprotein particle stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; intracellular signal transduction; JAK-STAT cascade; negative regulation of endothelial cell activation; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of inflammatory response; negative regulation of interleukin-6 production; negative regulation of monocyte chemotactic protein-1 production; negative regulation of signal transduction; negative regulation of T-helper 2 cell differentiation; phosphatidylinositol phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 1 cell differentiation; regulation of growth; vascular endothelial cell response to fluid shear stress
Reference #:  O54928 (UniProtKB)
Alt. Names/Synonyms: 1810018L08Rik; Cis; Cish5; cytokine inducible SH2-containing protein 5; Cytokine-inducible SH2-containing protein 5; KIAA0671; mKIAA0671; SOC; SOCS-5; Socs5; Suppressor of cytokine signaling 5
Gene Symbols: Socs5
Molecular weight: 61,086 Da
Basal Isoelectric point: 8.83  Predict pI for various phosphorylation states
CST Pathways:  IL6 Signaling
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene