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SOCS5
SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling. Note: This description may include information from UniProtKB.
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| Protein type: Inhibitor |
| Chromosomal Location of Human Ortholog: 17|17 E4 |
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Cellular Component:
cytoplasm; phosphatidylinositol 3-kinase complex
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Molecular Function:
1-phosphatidylinositol-3-kinase regulator activity; epidermal growth factor receptor binding; kinase inhibitor activity; protein binding; receptor tyrosine kinase binding
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Biological Process:
cellular response to low-density lipoprotein particle stimulus; cytokine-mediated signaling pathway; epidermal growth factor receptor signaling pathway; intracellular signal transduction; JAK-STAT cascade; negative regulation of endothelial cell activation; negative regulation of epidermal growth factor-activated receptor activity; negative regulation of inflammatory response; negative regulation of interleukin-6 production; negative regulation of monocyte chemotactic protein-1 production; negative regulation of signal transduction; negative regulation of T-helper 2 cell differentiation; phosphatidylinositol phosphorylation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; positive regulation of T-helper 1 cell differentiation; regulation of growth; vascular endothelial cell response to fluid shear stress
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Reference #:
O54928
(UniProtKB)
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Alt. Names/Synonyms: 1810018L08Rik; Cish5; cytokine inducible SH2-containing protein 5; Cytokine-inducible SH2-containing protein 5; KIAA0671; mKIAA0671; SOCS-5; Socs5; Suppressor of cytokine signaling 5
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Gene Symbols: Socs5
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Molecular weight:
61,086 Da
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Basal Isoelectric point:
8.83
Predict pI for various phosphorylation states
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CST Pathways:
IL6 Signaling
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