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TRAF4
Adapter protein and signal transducer that links members of the tumor necrosis factor receptor (TNFR) family to different signaling pathways. Plays a role in the activation of NF-kappa-B and JNK, and in the regulation of cell survival and apoptosis. Regulates activation of NF-kappa-B in response to signaling through Toll-like receptors. Required for normal skeleton development, and for normal development of the respiratory tract. Required for activation of RPS6KB1 in response to TNF signaling. Modulates TRAF6 functions. Belongs to the TNF receptor-associated factor family. B subfamily. Expressed in epithelial cells of thymus, dendritic cells of lymph node, and in the basal cell layer of epithelia such as epidermis, nasopharynx, respiratory tract, salivary gland, and esophagus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; DNA-binding; Ubiquitin conjugating system; Ubiquitin ligase |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
bicellular tight junction; cytoplasm; cytoskeleton; cytosol; fibrillar center; nucleoplasm; nucleus; perinuclear region of cytoplasm; plasma membrane; plasma membrane signaling receptor complex
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Molecular Function:
identical protein binding; protein binding; protein kinase binding; thioesterase binding; transferase activity; tumor necrosis factor receptor binding; ubiquitin protein ligase binding; WW domain binding; zinc ion binding
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Biological Process:
activation of NF-kappaB-inducing kinase activity; apoptotic process; innate immune response; positive regulation of JNK cascade; positive regulation of protein kinase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; regulation of apoptotic process; regulation of I-kappaB kinase/NF-kappaB signaling; respiratory gaseous exchange by respiratory system; respiratory tube development
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Reference #:
Q9BUZ4
(UniProtKB)
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Alt. Names/Synonyms: CART1; cysteine-rich domain associated with ring and TRAF domain; Cysteine-rich domain associated with RING and Traf domains protein 1; malignant 62; Metastatic lymph node gene 62 protein; MLN 62; MLN62; RING finger protein 83; RNF83; TNF receptor associated factor 4; TNF receptor-associated factor 4; TRAF4; TRAF4 variant 6; tumor necrosis receptor-associated factor 4A
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Gene Symbols: TRAF4
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Molecular weight:
53,543 Da
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Basal Isoelectric point:
8.54
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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