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POLR1B
a subunit of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase that synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the clef. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.6; Nucleolus; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase |
| Chromosomal Location of Human Ortholog: 2q14.1 |
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Cellular Component:
cytosol; DNA-directed RNA polymerase I complex; nucleolus; nucleoplasm
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Molecular Function:
DNA binding; DNA-directed RNA polymerase activity; metal ion binding; protein binding; ribonucleoside binding
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Biological Process:
embryo implantation; nucleologenesis; positive regulation of gene expression, epigenetic; rRNA transcription; termination of RNA polymerase I transcription; transcription initiation from RNA polymerase I promoter
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Reference #:
Q9H9Y6
(UniProtKB)
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Alt. Names/Synonyms: DNA-directed RNA polymerase I 135 kDa polypeptide; DNA-directed RNA polymerase I 135kDa polypeptide; DNA-directed RNA polymerase I subunit RPA2; FLJ10816; FLJ21921; MGC131780; POLR1B; polymerase (RNA) I polypeptide B, 128kDa; RNA polymerase I subunit 2; RPA135; RPA2; Rpo1-2
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Gene Symbols: POLR1B
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Molecular weight:
128,229 Da
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Basal Isoelectric point:
8.07
Predict pI for various phosphorylation states
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