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POLR1B
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. Belongs to the RNA polymerase beta chain family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.7.6; Nucleolus; Nucleotide Metabolism - purine; Nucleotide Metabolism - pyrimidine; Transcription initiation complex; Transferase |
| Chromosomal Location of human Ortholog: 2q14.1 |
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Cellular Component:
chromosome; cytosol; fibrillar center; nucleoplasm; RNA polymerase I complex
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Molecular Function:
DNA binding; metal ion binding; protein binding; ribonucleoside binding; RNA polymerase I activity
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Biological Process:
embryo implantation; neural crest formation; nucleologenesis; rRNA transcription; transcription by RNA polymerase I
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Disease: Treacher Collins Syndrome 4
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Reference #:
Q9H9Y6
(UniProtKB)
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Alt. Names/Synonyms: A135; DNA-directed RNA polymerase I 135 kDa polypeptide; DNA-directed RNA polymerase I 135kDa polypeptide; DNA-directed RNA polymerase I subunit RPA2; FLJ10816; FLJ21921; MGC131780; POLR1B; polymerase (RNA) I polypeptide B, 128kDa; polymerase (RNA) I subunit B; RNA polymerase I subunit 2; RNA polymerase I subunit B; RPA135; RPA2; Rpo1-2; TCS4
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Gene Symbols: POLR1B
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Molecular weight:
128,229 Da
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Basal Isoelectric point:
8.07
Predict pI for various phosphorylation states
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