FBXW7 iso3 Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination. Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1. Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation. SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1. Involved in bone homeostasis and negative regulation of osteoclast differentiation. Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination. Isoform 1 is widely expressed. Isoform 3 is expressed in brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nucleolus; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3 F1|3 37.7 cM
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; integral component of membrane; mitochondrion; nucleolus; nucleoplasm; nucleus; Parkin-FBXW7-Cul1 ubiquitin ligase complex; perinuclear region of cytoplasm; protein-containing complex; SCF ubiquitin ligase complex
Molecular Function:  cyclin binding; identical protein binding; phosphothreonine residue binding; protein binding; protein binding, bridging; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activator activity
Biological Process:  cellular response to DNA damage stimulus; cellular response to UV; lung development; negative regulation of DNA endoreduplication; negative regulation of gene expression; negative regulation of osteoclast development; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; Notch signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; positive regulation of proteasomal protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; protein destabilization; protein stabilization; protein ubiquitination; regulation of autophagy of mitochondrion; regulation of cell migration involved in sprouting angiogenesis; regulation of circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; ubiquitin recycling; vasculogenesis
Reference #:  D3YUA5 (UniProtKB)
Alt. Names/Synonyms: 1110001A17Rik; AGO; Cdc4; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; Fbxw7; OTTMUSP00000025917; SEL-10
Gene Symbols: Fbxw7
Molecular weight: 79,848 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
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FBXW7 iso3

Protein Structure Not Found.

Cross-references to other databases:  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene