FBXW7 iso3 a substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins including MYC, cyclin E, NOTCH1-released notch intracellular domain (NICD), JUN, and probably PSEN1. Recognizes and binds to phosphorylated target proteins. Other components of the SCF(FBXW7) complex are sCUL1, RBX1, and SKP1A. Defects in FBXW7 may be a cause of breast cancer. The homolog of Cdc4, one of the yeast genes that regulate sister chromatid cohesion. Down-regulation or disruption of FBXW7 resulted in abnormal sister chromatid cohesion in human cells. Four alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Nucleolus; Ubiquitin conjugating system
Chromosomal Location of Human Ortholog: 3 F1|3 37.7 cM
Cellular Component:  cytoplasm; endoplasmic reticulum; Golgi apparatus; integral component of membrane; mitochondrion; nucleolus; nucleoplasm; nucleus; Parkin-FBXW7-Cul1 ubiquitin ligase complex; perinuclear region of cytoplasm; protein-containing complex; SCF ubiquitin ligase complex
Molecular Function:  cyclin binding; identical protein binding; phosphothreonine residue binding; protein binding; protein binding, bridging; ubiquitin binding; ubiquitin protein ligase binding; ubiquitin-protein transferase activator activity
Biological Process:  cellular response to DNA damage stimulus; cellular response to UV; lung development; negative regulation of DNA endoreduplication; negative regulation of gene expression; negative regulation of osteoclast development; negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding; Notch signaling pathway; positive regulation of epidermal growth factor-activated receptor activity; positive regulation of ERK1 and ERK2 cascade; positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway; positive regulation of proteasomal protein catabolic process; positive regulation of protein targeting to mitochondrion; positive regulation of protein ubiquitination; positive regulation of ubiquitin-dependent protein catabolic process; positive regulation of ubiquitin-protein transferase activity; proteasome-mediated ubiquitin-dependent protein catabolic process; protein destabilization; protein stabilization; protein ubiquitination; regulation of autophagy of mitochondrion; regulation of cell migration involved in sprouting angiogenesis; regulation of circadian rhythm; SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; sister chromatid cohesion; ubiquitin recycling; vasculogenesis
Reference #:  D3YUA5 (UniProtKB)
Alt. Names/Synonyms: 1110001A17Rik; AGO; Cdc4; F-box and WD-40 domain protein 7; F-box and WD-40 domain protein 7, archipelago homolog; F-box and WD-40 domain-containing protein 7; f-box only protein 30; F-box protein FBW7; F-box protein Fbxw6; F-box-WD40 repeat protein 6; F-box/WD repeat-containing protein 7; Fbw7; Fbwd6; Fbx30; Fbxo30; Fbxw6; Fbxw7; OTTMUSP00000025917; SEL-10
Gene Symbols: Fbxw7
Molecular weight: 79,848 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Select Structure to View Below

FBXW7 iso3

Protein Structure Not Found.


Cross-references to other databases:  Pfam  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene