UBA52 Ubiquitin: Exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, DNA-damage responses as well as in signaling processes leading to activation of the transcription factor NF-kappa-B. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling. 60S ribosomal protein L40: Component of the 60S subunit of the ribosome. Ribosomal protein L40 is essential for translation of a subset of cellular transcripts, and especially for cap-dependent translation of vesicular stomatitis virus mRNAs. In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family. Note: This description may include information from UniProtKB.

Protein type: Ribosomal; Translation

Chromosomal Location of human Ortholog: 19p13.11

Cellular Component: cytoplasm; cytosol; cytosolic large ribosomal subunit; cytosolic ribosome; cytosolic small ribosomal subunit; endocytic vesicle membrane; endoplasmic reticulum; endoplasmic reticulum membrane; endosome membrane; mitochondrial outer membrane; nucleoplasm; nucleus; plasma membrane; synapse

Molecular Function: protein binding; protein tag activity; structural constituent of ribosome; ubiquitin protein ligase binding

Biological Process: cytoplasmic translation; modification-dependent protein catabolic process; protein modification process; protein ubiquitination

Reference #: P62987 (UniProtKB)

Alt. Names/Synonyms: 60S ribosomal protein L40; CEP52; HUBCEP52; L40; Large ribosomal subunit protein eL40; MGC126879; MGC126881; MGC57125; ribosomal protein L40; RL40; RPL40; UBA52; UBCEP2; Ubiquitin; ubiquitin A-52 residue ribosomal protein fusion product 1; ubiquitin and ribosomal protein L40; ubiquitin carboxyl extension protein 52; ubiquitin-52 amino acid fusion protein; Ubiquitin-60S ribosomal protein L40; ubiquitin-CEP52; Ubiquitin-ribosomal protein eL40 fusion protein

Gene Symbols: UBA52

Molecular weight: 14,728 Da

Basal Isoelectric point: 9.87 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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UBA52

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