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OSMR
Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Belongs to the type I cytokine receptor family. Type 2 subfamily. Expressed in keratinocytes (at protein level) (PubMed:21261663). Expressed at relatively high levels in all neural cells as well as fibroblast and epithelial cells (PubMed:8999038). 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral; Receptor, cytokine |
| Chromosomal Location of mouse Ortholog: 15 A1|15 3.3 cM |
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Cellular Component:
apical plasma membrane; external side of plasma membrane; membrane; oncostatin-M receptor complex; plasma membrane; receptor complex
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Molecular Function:
ciliary neurotrophic factor receptor binding; cytokine binding; cytokine receptor activity; growth factor binding; leukemia inhibitory factor receptor activity; oncostatin-M receptor activity
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Biological Process:
cell surface receptor signaling pathway; cytokine-mediated signaling pathway; oncostatin-M-mediated signaling pathway; positive regulation of cell population proliferation; response to cytokine
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Reference #:
O70458
(UniProtKB)
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Alt. Names/Synonyms: IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; oncostatin M receptor; oncostatin receptor; oncostatin-M specific receptor subunit beta; Oncostatin-M-specific receptor subunit beta; Osmr; Osmrb
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Gene Symbols: Osmr
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Molecular weight:
110,229 Da
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Basal Isoelectric point:
6.16
Predict pI for various phosphorylation states
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