OSMR Associates with IL31RA to form the IL31 receptor. Binds IL31 to activate STAT3 and possibly STAT1 and STAT5. Capable of transducing OSM-specific signaling events. Defects in OSMR are the cause of amyloidosis primary localized cutaneous type 1 (PLCA1); also known as familial lichen amyloidosis or familial cutaneous lichen amyloidosis. PLCA1 is a hereditary primary amyloidosis characterized by localized cutaneous amyloid deposition. This condition usually presents with itching (especially on the lower legs) and visible changes of skin hyperpigmentation and thickening (lichenification) that may be exacerbated by chronic scratching and rubbing. The amyloid deposits probably reflect a combination of degenerate keratin filaments, serum amyloid P component, and deposition of immunoglobulins. Belongs to the type I cytokine receptor family. Type 2 subfamily. 2 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Receptor, cytokine
Chromosomal Location of Human Ortholog: 5p13.1
Cellular Component:  apical plasma membrane; oncostatin-M receptor complex; plasma membrane
Molecular Function:  growth factor binding; protein binding
Biological Process:  cytokine-mediated signaling pathway; oncostatin-M-mediated signaling pathway; positive regulation of acute inflammatory response; positive regulation of cell proliferation; response to cytokine
Disease: Amyloidosis, Primary Localized Cutaneous, 1
Reference #:  Q99650 (UniProtKB)
Alt. Names/Synonyms: IL-31 receptor subunit beta; IL-31R subunit beta; IL-31R-beta; IL-31RB; Interleukin-31 receptor subunit beta; MGC150626; MGC150627; MGC75127; oncostatin M receptor; oncostatin-M specific receptor beta subunit; Oncostatin-M-specific receptor subunit beta; OSMR; OSMRB
Gene Symbols: OSMR
Molecular weight: 110,509 Da
Basal Isoelectric point: 5.54  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein