UNC13B Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family. Expressed in kidney cortical epithelial cells and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of mouse Ortholog: 4|4 A5
Cellular Component:  calyx of Held; cytoplasm; cytosol; early phagosome; glutamatergic synapse; Golgi apparatus; hippocampal mossy fiber to CA3 synapse; membrane; neuromuscular junction; plasma membrane; presynapse; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; ribbon synapse; synapse; synaptic membrane; synaptic vesicle membrane; terminal bouton
Molecular Function:  calcium ion binding; calmodulin binding; diacylglycerol binding; GTP-dependent protein binding; metal ion binding; non-kinase phorbol ester receptor activity; phospholipid binding; syntaxin binding; syntaxin-1 binding
Biological Process:  acrosomal vesicle exocytosis; cellular response to glucose stimulus; chemical synaptic transmission; dense core granule docking; dense core granule priming; exocytosis; innervation; negative regulation of synaptic plasticity; neuromuscular junction development; neuronal dense core vesicle exocytosis; phagosome maturation; positive regulation of apoptotic process; positive regulation of defense response to bacterium; positive regulation of exocytosis; positive regulation of inhibitory postsynaptic potential; positive regulation of protein secretion; positive regulation of synaptic vesicle priming; presynaptic dense core vesicle exocytosis; regulation of presynaptic dense core granule exocytosis; regulation of short-term neuronal synaptic plasticity; spontaneous neurotransmitter secretion; synaptic transmission, glutamatergic; synaptic vesicle docking; synaptic vesicle exocytosis; synaptic vesicle maturation; synaptic vesicle priming
Reference #:  Q9Z1N9 (UniProtKB)
Alt. Names/Synonyms: munc13; Munc13-; Munc13-1; Munc13-2; Protein unc-13 homolog B; UN13B; UNC-13 homolog 1; unc-13 homolog A; unc-13 homolog B; unc-13 homolog B (C. elegans); unc13 homolog 1; Unc13a; Unc13b; Unc13h; Unc13h1; Unc13h2
Gene Symbols: Unc13b
Molecular weight: 181,813 Da
Basal Isoelectric point: 5.64  Predict pI for various phosphorylation states
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UNC13B

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene