UNC13B Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family. Expressed in kidney cortical epithelial cells and brain. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of human Ortholog: 9p13.3
Cellular Component:  calyx of Held; cell junction; cytosol; early phagosome; glutamatergic synapse; Golgi apparatus; hippocampal mossy fiber to CA3 synapse; membrane; plasma membrane; presynaptic active zone; ribbon synapse; terminal bouton
Molecular Function:  calcium ion binding; calmodulin binding; diacylglycerol binding; GTP-dependent protein binding; phospholipid binding; protein binding; Rab GTPase binding
Biological Process:  acrosomal vesicle exocytosis; cellular response to glucose stimulus; chemical synaptic transmission; glutamate secretion; innervation; intracellular signal transduction; negative regulation of synaptic plasticity; neurotransmitter secretion; phagosome maturation; positive regulation of apoptotic process; positive regulation of defense response to bacterium; positive regulation of inhibitory postsynaptic potential; positive regulation of protein secretion; positive regulation of synaptic vesicle priming; regulation of short-term neuronal synaptic plasticity; synaptic vesicle priming
Reference #:  O14795 (UniProtKB)
Alt. Names/Synonyms: hmunc13; homolog of rat Munc13 (diacylglycerol-binding); MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B; unc-13 homolog B; unc-13 homolog B (C. elegans); unc-13-like; UNC13; UNC13-like; UNC13B; Unc13h2
Gene Symbols: UNC13B
Molecular weight: 180,679 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene