UNC13B Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity- depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses. Belongs to the unc-13 family. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 9p13.3
Cellular Component:  calyx of Held; cell junction; cytosol; Golgi apparatus; membrane; neuromuscular junction; plasma membrane; presynaptic active zone; presynaptic active zone cytoplasmic component; presynaptic membrane; synaptic vesicle membrane; terminal bouton
Molecular Function:  calcium ion binding; calmodulin binding; diacylglycerol binding; GTP-dependent protein binding; phospholipid binding; protein binding; Rab GTPase binding; syntaxin-1 binding
Biological Process:  cellular response to glucose stimulus; dense core granule priming; negative regulation of synaptic plasticity; neuromuscular junction development; phagosome maturation; positive regulation of apoptosis; positive regulation of defense response to bacterium; positive regulation of protein secretion; positive regulation of synaptic vesicle priming; regulation of short-term neuronal synaptic plasticity; synaptic transmission; synaptic transmission, glutamatergic; synaptic vesicle docking during exocytosis; synaptic vesicle maturation; synaptic vesicle priming
Reference #:  O14795 (UniProtKB)
Alt. Names/Synonyms: hmunc13; homolog of rat Munc13 (diacylglycerol-binding); MGC133279; MGC133280; munc13; Munc13-2; Protein unc-13 homolog B; UN13B; unc-13 homolog B (C. elegans); unc-13-like; UNC13; UNC13-like; UNC13B; Unc13h2
Gene Symbols: UNC13B
Molecular weight: 180,679 Da
Basal Isoelectric point: 5.67  Predict pI for various phosphorylation states
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Protein Structure Not Found.

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