CNP
May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. Belongs to the 2H phosphoesterase superfamily. CNPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cell development/differentiation; EC 3.1.4.37; Phosphodiesterase |
Chromosomal Location of human Ortholog: 17q21.2 |
Cellular Component:
cytoplasm; extracellular space; melanosome; microvillus; mitochondrial inner membrane; mitochondrial outer membrane; myelin sheath abaxonal region; myelin sheath adaxonal region; perinuclear region of cytoplasm; plasma membrane; pseudopodium; synapse
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Molecular Function:
2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; cyclic nucleotide binding; protein binding; RNA binding
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Biological Process:
adult locomotory behavior; axonogenesis; chemical synaptic transmission; cyclic nucleotide catabolic process; forebrain development; oligodendrocyte differentiation; regulation of mitochondrial membrane permeability; response to lipopolysaccharide; response to toxic substance
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Disease: Leukodystrophy, Hypomyelinating, 20
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Reference #:
P09543
(UniProtKB)
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Alt. Names/Synonyms: 2', 3' cyclic nucleotide 3' phosphohydrolase; 2',3'-cyclic nucleotide 3' phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CN37; CNP; CNP1; CNPase
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Gene Symbols: CNP
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Molecular weight:
47,579 Da
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Basal Isoelectric point:
9.17
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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