AK2 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis. Belongs to the adenylate kinase family. AK2 subfamily. Present in most tissues. Present at high level in heart, liver and kidney, and at low level in brain, skeletal muscle and skin. Present in thrombocytes but not in erythrocytes, which lack mitochondria. Present in all nucleated cell populations from blood, while AK1 is mostly absent. In spleen and lymph nodes, mononuclear cells lack AK1, whereas AK2 is readily detectable. These results indicate that leukocytes may be susceptible to defects caused by the lack of AK2, as they do not express AK1 in sufficient amounts to compensate for the AK2 functional deficits (at protein level). 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, other; Mitochondrial; Nucleotide Metabolism - purine
Chromosomal Location of mouse Ortholog: 4 D2.2|4 62.62 cM
Cellular Component:  cytoplasm; cytosol; mitochondrial intermembrane space; mitochondrion; nucleus; sperm flagellum; sperm mitochondrial sheath
Molecular Function:  adenylate kinase activity; ATP binding; kinase activity; nucleotide binding; phosphotransferase activity, phosphate group as acceptor; transferase activity
Biological Process:  ADP biosynthetic process; AMP metabolic process; ATP metabolic process; dATP metabolic process; nucleobase-containing compound metabolic process; phosphorylation
Reference #:  Q9WTP6 (UniProtKB)
Alt. Names/Synonyms: adenylate kinase 2; Adenylate kinase 2, mitochondrial; Adenylate monophosphate kinase; AK 2; Ak-; Ak-2; Ak2; ATP-AMP transphosphorylase 2; ATP:AMP phosphotransferase; D4Ertd220; D4Ertd220e; KAD2; OTTMUSP00000010093; OTTMUSP00000010094
Gene Symbols: Ak2
Molecular weight: 26,469 Da
Basal Isoelectric point: 6.96  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene