NHP2L1 Involved in pre-mRNA splicing as component of the spliceosome. Binds to the 5'-stem-loop of U4 snRNA and thereby contributes to spliceosome assembly. The protein undergoes a conformational change upon RNA-binding. Belongs to the eukaryotic ribosomal protein eL8 family. Ubiquitous. Note: This description may include information from UniProtKB.
Protein type: Nucleolus; RNA splicing; RNA-binding; Spliceosome
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  box C/D snoRNP complex; dense fibrillar component; nucleolus; nucleoplasm; nucleus; protein-containing complex; U2-type precatalytic spliceosome; U4/U6 x U5 tri-snRNP complex; U4atac snRNP
Molecular Function:  ATPase binding; box C/D snoRNA binding; protein binding; U3 snoRNA binding; U4 snRNA binding; U4atac snRNA binding
Biological Process:  box C/D snoRNP assembly; mRNA splicing, via spliceosome; rRNA processing; single fertilization
Reference #:  P55769 (UniProtKB)
Alt. Names/Synonyms: 15.5K; [U4/U6.U5] tri-snRNP 15.5 kD RNA binding protein; FA-1; FA1; High mobility group-like nuclear protein 2 homolog 1; hSNU13; NH2L1; NHP2 non-histone chromosome protein 2-like 1; NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae); NHP2-like protein 1; NHP2-like protein 1, N-terminally processed; NHP2L1; NHPX; non-histone chromosome protein 2-like 1; OTK27; small nuclear ribonucleoprotein 13; small nuclear ribonucleoprotein 15.5kDa (U4/U6.U5); SNRNP15-5; SNU13; SNU13 homolog; SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5); SPAG12; sperm specific antigen 1; SSFA1; U4/U6.U5 small nuclear ribonucleoprotein SNU13; U4/U6.U5 tri-snRNP 15.5 kDa protein
Gene Symbols: SNU13
Molecular weight: 14,174 Da
Basal Isoelectric point: 8.72  Predict pI for various phosphorylation states
Select Structure to View Below

NHP2L1

Protein Structure Not Found.


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