RAB34 Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Belongs to the small GTPase superfamily. Rab family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: G protein, monomeric; G protein, monomeric, Rab; Nucleolus
Chromosomal Location of Human Ortholog: 11 B5|11 46.74 cM
Cellular Component:  cell projection; cytoplasm; cytoplasmic vesicle; early endosome; Golgi apparatus; Golgi cisterna; Golgi stack; late endosome; membrane; perinuclear region of cytoplasm; phagocytic vesicle; ruffle; vesicle
Molecular Function:  GTP binding; GTP-dependent protein binding; GTPase activity; guanyl nucleotide binding; nucleotide binding; protein binding; Ral GTPase binding
Biological Process:  antigen processing and presentation; cell projection organization; cellular response to glucose stimulus; endocytosis; Golgi to plasma membrane protein transport; intracellular protein transport; lysosomal transport; lysosome localization; phagosome maturation; phagosome-lysosome fusion; positive regulation of defense response to bacterium; positive regulation of protein localization to phagocytic vesicle; positive regulation of protein secretion; positive regulation of smoothened signaling pathway; protein localization to plasma membrane; protein transport; Rab protein signal transduction
Reference #:  Q64008 (UniProtKB)
Alt. Names/Synonyms: AI326479; NARR; OTTMUSP00000000146; OTTMUSP00000000148; rab-39; Rab34; RAB34, member of RAS oncogene family; RAB34, member RAS oncogene family; Rab39; Rah; Rah1; Ras-related homolog; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah
Gene Symbols: Rab34
Molecular weight: 29,101 Da
Basal Isoelectric point: 8.55  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene