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RAB34
Protein transport. Involved in the redistribution of lysosomes to the peri-Golgi region. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. Plays a role in the fusion of phagosomes with lysosomes. Acts also as a positive regulator of hedgehog signaling and regulates ciliary function. Belongs to the small GTPase superfamily. Rab family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: G protein, monomeric; G protein, monomeric, Rab; Nucleolus |
| Chromosomal Location of human Ortholog: 17q11.2 |
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Cellular Component:
cilium; Golgi apparatus; Golgi cisterna; Golgi stack; perinuclear region of cytoplasm; phagocytic vesicle; phagocytic vesicle membrane; ruffle membrane; vesicle
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Molecular Function:
GTP binding; GTP-dependent protein binding; GTPase activity; protein binding; small GTPase binding
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Biological Process:
antigen processing and presentation; cell projection organization; Golgi to plasma membrane protein transport; lysosome localization; macropinocytosis; phagosome maturation; phagosome-lysosome fusion; positive regulation of smoothened signaling pathway; protein localization to plasma membrane
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Disease: Orofaciodigital Syndrome Xx
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Reference #:
Q9BZG1
(UniProtKB)
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Alt. Names/Synonyms: NARR; nine amino-acid residue-repeats; RAB34; RAB34, member RAS oncogene family; RAB39; RAH; Ras-related protein Rab-34; Ras-related protein Rab-39; Ras-related protein Rah
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Gene Symbols: RAB34
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Molecular weight:
29,044 Da
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Basal Isoelectric point:
8.07
Predict pI for various phosphorylation states
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