SLC1A5 Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of mouse Ortholog: 7|7 A2
Cellular Component:  basal plasma membrane; membrane; plasma membrane
Molecular Function:  L-aspartate transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-serine transmembrane transporter activity; metal ion binding; neutral amino acid transmembrane transporter activity; symporter activity
Biological Process:  amino acid transmembrane transport; amino acid transport; glutamine secretion; glutamine transport; L-aspartate import across plasma membrane; L-glutamine import across plasma membrane; L-serine transport; neutral amino acid transport; protein homotrimerization; transport across blood-brain barrier
Reference #:  P51912 (UniProtKB)
Alt. Names/Synonyms: Aaat; ASC; ASC-like Na(+)-dependent neutral amino acid transporter ASCT2; Asct2; ATB(0); ATBO; Insulin-activated amino acid transporter; M7V1; M7VS1; MGC46952; Neutral amino acid transporter B(0); OTTMUSP00000025145; R16; RDRC; Slc1a5; Slc1a7; Sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5; solute carrier family 1, member 7
Gene Symbols: Slc1a5
Molecular weight: 58,483 Da
Basal Isoelectric point: 8.14  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene