SLC1A5 Sodium-dependent amino acids transporter that has a broad substrate specificity, with a preference for zwitterionic amino acids. It accepts as substrates all neutral amino acids, including glutamine, asparagine, and branched-chain and aromatic amino acids, and excludes methylated, anionic, and cationic amino acids. Through binding of the fusogenic protein syncytin-1/ERVW-1 may mediate trophoblasts syncytialization, the spontaneous fusion of their plasma membranes, an essential process in placental development. (Microbial infection) Acts as a cell surface receptor for Feline endogenous virus RD114. (Microbial infection) Acts as a cell surface receptor for Baboon M7 endogenous virus. (Microbial infection) Acts as a cell surface receptor for type D simian retroviruses. Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A5 subfamily. Placenta, lung, skeletal muscle, kidney, pancreas, and intestine. 3 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 19q13.32
Cellular Component:  integral component of membrane; integral component of plasma membrane; melanosome; plasma membrane
Molecular Function:  amino acid transmembrane transporter activity; L-glutamine transmembrane transporter activity; L-serine transmembrane transporter activity; metal ion binding; neutral amino acid transmembrane transporter activity; protein binding; signaling receptor activity; symporter activity; virus receptor activity
Biological Process:  amino acid transport; glutamine secretion; glutamine transport; L-glutamine import across plasma membrane; L-serine transport; neutral amino acid transport; protein homotrimerization; viral entry into host cell
Reference #:  Q15758 (UniProtKB)
Alt. Names/Synonyms: AAAT; ASCT2; ATB(0); ATBO; Baboon M7 virus receptor; FLJ31068; M7V1; M7VS1; neutral amino acid transporter B; Neutral amino acid transporter B(0); R16; RD114 virus receptor; RD114/simian type D retrovirus receptor; RDR; RDRC; SLC1A5; Sodium-dependent neutral amino acid transporter type 2; solute carrier family 1 (neutral amino acid transporter), member 5; Solute carrier family 1 member 5
Gene Symbols: SLC1A5
Molecular weight: 56,598 Da
Basal Isoelectric point: 5.34  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene