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MEK5
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Expressed in many adult tissues. Abundant in heart and skeletal muscle. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 2.7.12.2; Kinase, protein; MEK5 subfamily; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family |
| Chromosomal Location of human Ortholog: 15q23 |
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Cellular Component:
spindle
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Molecular Function:
ATP binding; MAP kinase kinase activity; metal ion binding; protein binding; protein kinase activity; protein serine kinase activity; protein serine/threonine kinase activity; protein tyrosine kinase activity
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Biological Process:
cellular response to growth factor stimulus; cellular response to laminar fluid shear stress; ERK5 cascade; heart development; insulin-like growth factor receptor signaling pathway; MAPK cascade; negative regulation of cell migration involved in sprouting angiogenesis; negative regulation of chemokine (C-X-C motif) ligand 2 production; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; negative regulation of extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of heterotypic cell-cell adhesion; negative regulation of interleukin-8 production; negative regulation of NF-kappaB transcription factor activity; negative regulation of response to cytokine stimulus; negative regulation of transcription by RNA polymerase II; positive regulation of cell growth; positive regulation of epithelial cell proliferation; positive regulation of MAP kinase activity; positive regulation of protein metabolic process; positive regulation of transcription by RNA polymerase II; protein phosphorylation; signal transduction
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Reference #:
Q13163
(UniProtKB)
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Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 5; HsT17454; MAP kinase kinase 5; MAP kinase kinase MEK5b; MAP2K5; MAPK/ERK kinase 5; MAPKK 5; MAPKK5; MEK 5; MEK5; mitogen-activated protein kinase kinase 5; MKK5; MP2K5; PRKMK5
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Gene Symbols: MAP2K5
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Molecular weight:
50,112 Da
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Basal Isoelectric point:
5.98
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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IL6 Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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