ZNF91 Transcription factor specifically required to repress SINE-VNTR-Alu (SVA) retrotransposons: recognizes and binds SVA sequences and represses their expression by recruiting a repressive complex containing TRIM28/KAP1. May also bind the promoter of the FCGR2B gene, leading to repress its expression; however, additional evidence is required to confirm this result in vivo. Belongs to the krueppel C2H2-type zinc-finger protein family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: C2H2-type zinc finger protein; DNA-binding
Chromosomal Location of human Ortholog: 19p12
Cellular Component:  nucleus
Molecular Function:  DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; zinc ion binding
Biological Process:  negative regulation of transcription, DNA-templated; negative regulation of transposon integration; regulation of transcription by RNA polymerase II
Reference #:  Q05481 (UniProtKB)
Alt. Names/Synonyms: HPF7; HTF10; Zinc finger protein 91; zinc finger protein 91 (HPF7, HTF10); Zinc finger protein HPF7; Zinc finger protein HTF10; ZNF91
Gene Symbols: ZNF91
Molecular weight: 137,217 Da
Basal Isoelectric point: 9.45  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene