epsin 1 Binds to membranes enriched in phosphatidylinositol 4,5- bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis. Belongs to the epsin family. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 7|7 A1
Cellular Component:  clathrin-coated pit; cytoplasm; cytosol; extrinsic component of cytoplasmic side of plasma membrane; extrinsic component of postsynaptic membrane; extrinsic component of presynaptic membrane; membrane; nucleus; plasma membrane; postsynapse; presynapse; Schaffer collateral - CA1 synapse
Molecular Function:  clathrin adaptor activity; ion channel binding; lipid binding; transcription factor binding
Biological Process:  embryonic organ development; endocytosis; female pregnancy; in utero embryonic development; negative regulation of sprouting angiogenesis; Notch signaling pathway; positive regulation of clathrin coat assembly
Reference #:  Q80VP1 (UniProtKB)
Alt. Names/Synonyms: AA269831; Epn1; EPS-15-interacting protein 1; epsin 1; Epsin-1; Ibp1; Intersectin-EH-binding protein 1; MGC106041; OTTMUSP00000032065; OTTMUSP00000032066
Gene Symbols: Epn1
Molecular weight: 60,212 Da
Basal Isoelectric point: 4.69  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Select Structure to View Below

epsin 1

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene