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epsin 1
Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis. Belongs to the epsin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Motility/polarity/chemotaxis; Vesicle |
| Chromosomal Location of human Ortholog: 19q13.42 |
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Cellular Component:
clathrin vesicle coat; clathrin-coated pit; cytosol; endosome; nucleus; plasma membrane
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Molecular Function:
clathrin binding; molecular sequestering activity; phospholipid binding; protein binding
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Biological Process:
embryonic organ development; endocytosis; female pregnancy; in utero embryonic development; negative regulation of sprouting angiogenesis; Notch signaling pathway
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Reference #:
Q9Y6I3
(UniProtKB)
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Alt. Names/Synonyms: EH domain-binding mitotic phosphoprotein; EPN1; EPS-15-interacting protein 1; epsin 1; Epsin-1
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Gene Symbols: EPN1
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Molecular weight:
60,293 Da
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Basal Isoelectric point:
4.72
Predict pI for various phosphorylation states
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CST Pathways:
Notch Signaling
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