epsin 1 Binds to membranes enriched in phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Modifies membrane curvature and facilitates the formation of clathrin-coated invaginations. Regulates receptor-mediated endocytosis. Belongs to the epsin family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Motility/polarity/chemotaxis; Vesicle
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component:  clathrin-coated pit; cytosol; nucleus; plasma membrane
Molecular Function:  lipid binding; protein binding
Biological Process:  embryonic organ development; endocytosis; female pregnancy; in utero embryonic development; membrane organization; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of sprouting angiogenesis; Notch signaling pathway
Reference #:  Q9Y6I3 (UniProtKB)
Alt. Names/Synonyms: EH domain-binding mitotic phosphoprotein; EPN1; EPS-15-interacting protein 1; epsin 1; Epsin-1
Gene Symbols: EPN1
Molecular weight: 60,293 Da
Basal Isoelectric point: 4.72  Predict pI for various phosphorylation states
CST Pathways:  Notch Signaling
Select Structure to View Below

epsin 1

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein