E2A Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of mouse Ortholog: 10 C1|10 39.72 cM
Cellular Component:  chromatin; cytoplasm; cytosol; euchromatin; nucleoplasm; nucleosome; nucleus; protein-containing complex; RNA polymerase II transcription regulator complex; transcription regulator complex
Molecular Function:  bHLH transcription factor binding; chromatin binding; cis-regulatory region sequence-specific DNA binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; identical protein binding; mitogen-activated protein kinase kinase kinase binding; PDZ domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; RNA polymerase II-specific DNA-binding transcription factor binding; sequence-specific DNA binding; transcription cis-regulatory region binding; vitamin D response element binding
Biological Process:  B cell lineage commitment; cell development; cell differentiation; chromatin remodeling; erythrocyte differentiation; gastrulation; gene expression; immunoglobulin V(D)J recombination; lymphocyte differentiation; natural killer cell differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; Peyer's patch development; positive regulation of B cell proliferation; positive regulation of cell cycle; positive regulation of DNA-binding transcription factor activity; positive regulation of DNA-templated transcription; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; protein stabilization; regulation of DNA-templated transcription; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; response to lipopolysaccharide; response to xenobiotic stimulus; T cell differentiation in thymus; transcription by RNA polymerase II
Reference #:  P15806 (UniProtKB)
Alt. Names/Synonyms: A1; AA408400; Alf2; AW209082; bHLHb2; bHLHb21; E12; E12/E47; E2A; E47; Immunoglobulin enhancer-binding factor E12/E47; KA1; Me2; OTTMUSP00000020636; Pan1; Pan2; TCF-3; Tcf3; Tcfe2; Tcfe2a; TFE2; Transcription factor 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; VDIR
Gene Symbols: Tcf3
Molecular weight: 67,701 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein