E2A a transcription factor that plays major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Heterodimers between E2A and tissue-specific basic helix-loop-helix (bHLH) Dimers bind DNA on E-box motifs: 5'- CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Deletions in E2A have been observed in a subset of pre-B-cell acute lymphoblastic leukemia (B-ALL) cases. Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 10 C1|10 39.72 cM
Cellular Component:  cytoplasm; nuclear chromatin; nuclear nucleosome; nuclear speck; nucleus; protein-containing complex; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  bHLH transcription factor binding; chromatin binding; DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; mitogen-activated protein kinase kinase kinase binding; PDZ domain binding; protein binding; protein dimerization activity; protein heterodimerization activity; protein homodimerization activity; repressing transcription factor binding; RNA polymerase II distal enhancer sequence-specific DNA binding; RNA polymerase II proximal promoter sequence-specific DNA binding; sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; vitamin D response element binding
Biological Process:  B cell lineage commitment; cell development; cell differentiation; erythrocyte differentiation; gastrulation; histone H3 acetylation; histone H4 acetylation; immunoglobulin V(D)J recombination; lymphocyte differentiation; natural killer cell differentiation; negative regulation of erythrocyte differentiation; negative regulation of transcription by RNA polymerase II; nervous system development; Peyer's patch development; positive regulation of B cell proliferation; positive regulation of cell cycle; positive regulation of DNA-binding transcription factor activity; positive regulation of gene expression; positive regulation of neuron differentiation; positive regulation of protein tyrosine kinase activity; positive regulation of signaling receptor activity; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; protein stabilization; regulation of G1/S transition of mitotic cell cycle; regulation of transcription by RNA polymerase II; regulation of transcription, DNA-templated; response to drug; response to lipopolysaccharide; T cell differentiation in thymus; transcription by RNA polymerase II; transcription, DNA-templated
Reference #:  P15806 (UniProtKB)
Alt. Names/Synonyms: A1; AA408400; Alf2; AW209082; bHLHb21; E12; E12/E47; E2A; E47; Immunoglobulin enhancer-binding factor E12/E47; Me2; OTTMUSP00000020636; Pan1; Pan2; TCF-3; Tcf3; Tcfe2a; TFE2; Transcription factor 3; Transcription factor A1; Transcription factor E2-alpha; transcription factor E2a; VDIR
Gene Symbols: Tcf3
Molecular weight: 67,701 Da
Basal Isoelectric point: 5.94  Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein