E2A Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell development/differentiation; DNA-binding; Oncoprotein; Transcription factor
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cytoplasm; nuclear chromatin; nuclear speck; nucleoplasm; nucleus; RNA polymerase II transcription factor complex; transcription factor complex
Molecular Function:  bHLH transcription factor binding; DNA binding; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; E-box binding; enhancer binding; mitogen-activated protein kinase kinase kinase binding; protein binding; protein heterodimerization activity; protein homodimerization activity; repressing transcription factor binding; RNA polymerase II proximal promoter sequence-specific DNA binding; transcription coactivator activity; transcription factor binding; vitamin D response element binding
Biological Process:  B cell differentiation; B cell lineage commitment; immunoglobulin V(D)J recombination; negative regulation of transcription by RNA polymerase II; positive regulation of DNA-binding transcription factor activity; positive regulation of muscle cell differentiation; positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription, DNA-templated; regulation of hematopoietic stem cell differentiation; regulation of transcription, DNA-templated; transcription, DNA-templated
Disease: Agammaglobulinemia 8, Autosomal Dominant
Reference #:  P15923 (UniProtKB)
Alt. Names/Synonyms: BHLHB21; Class B basic helix-loop-helix protein 21; E2A; E2A immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin enhancer-binding factor E12/E47; Immunoglobulin transcription factor 1; ITF1; Kappa-E2-binding factor; MGC129647; MGC129648; TCF-3; TCF3; TFE2; Transcription factor 3; transcription factor 3 (E2A immunoglobulin enhancer binding factors E12/E47); Transcription factor E2-alpha; Transcription factor ITF-1; VDIR; VDR interacting repressor
Gene Symbols: TCF3
Molecular weight: 67,600 Da
Basal Isoelectric point: Predict pI for various phosphorylation states
CST Pathways:  Adherens Junction Dynamics  |  Wnt/ß-Catenin Signaling
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein