CXADR Component of the epithelial apical junction complex that may function as a homophilic cell adhesion molecule and is essential for tight junction integrity. Also involved in transepithelial migration of leukocytes through adhesive interactions with JAML a transmembrane protein of the plasma membrane of leukocytes. The interaction between both receptors also mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. (Microbial infection) Acts as a receptor for adenovirus type C. (Microbial infection) Acts as a receptor for Coxsackievirus B1 to B6. Expressed in pancreas, brain, heart, small intestine, testis, prostate and at a lower level in liver and lung. Isoform 5 is ubiquitously expressed. Isoform 3 is expressed in heart, lung and pancreas. In skeletal muscle, isoform 1 is found at the neuromuscular junction and isoform 2 is found in blood vessels. In cardiac muscle, isoform 1 and isoform 2 are found at intercalated disks. In heart expressed in subendothelial layers of the vessel wall but not in the luminal endothelial surface. Expression is elevated in hearts with dilated cardiomyopathy. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral; Receptor, misc.
Chromosomal Location of Human Ortholog: 16|16 C3.1
Cellular Component:  acrosomal vesicle; adherens junction; apicolateral plasma membrane; basolateral plasma membrane; bicellular tight junction; cell body; cell junction; cell-cell adherens junction; cell-cell junction; cytoplasm; extracellular region; extracellular space; filopodium; growth cone; integral component of membrane; intercalated disc; membrane; membrane raft; neuromuscular junction; neuron projection; nucleoplasm; plasma membrane; protein-containing complex
Molecular Function:  beta-catenin binding; cell adhesion molecule binding; cell adhesive protein binding involved in AV node cell-bundle of His cell communication; connexin binding; identical protein binding; integrin binding; PDZ domain binding; protein binding; signaling receptor binding
Biological Process:  actin cytoskeleton reorganization; AV node cell to bundle of His cell communication; AV node cell-bundle of His cell adhesion involved in cell communication; cardiac muscle fiber development; cell adhesion; cell-cell adhesion; cell-cell junction organization; defense response to virus; epithelial structure maintenance; gamma-delta T cell activation; germ cell migration; heart development; heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; homotypic cell-cell adhesion; mitochondrion organization; negative regulation of cardiac muscle cell proliferation; neutrophil chemotaxis; positive regulation of epithelial cell proliferation involved in wound healing; regulation of AV node cell action potential; transepithelial transport
Reference #:  P97792 (UniProtKB)
Alt. Names/Synonyms: 2610206D03Rik; AU016810; AW553441; CAR; coxsackie virus and adenovirus receptor; Coxsackievirus and adenovirus receptor homolog; Cxadr; CXAR; mCAR; MCVADR; OTTMUSP00000015903; OTTMUSP00000015904
Gene Symbols: Cxadr
Molecular weight: 39,948 Da
Basal Isoelectric point: 6.54  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene