MEK2 Catalyzes the concomitant phosphorylation of a threonine and a tyrosine residue in a Thr-Glu-Tyr sequence located in MAP kinases. Activates the ERK1 and ERK2 MAP kinases. Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase subfamily. Note: This description may include information from UniProtKB.
Protein type: EC; Kinase, protein; Protein kinase, STE; Protein kinase, dual-specificity (non-receptor); STE group; STE7 family
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  cell-cell junction; cytoplasmic side of plasma membrane; cytosol; early endosome; endoplasmic reticulum; extracellular region; focal adhesion; Golgi apparatus; late endosome; microtubule; mitochondrion; nucleus; perinuclear region of cytoplasm
Molecular Function:  ATP binding; MAP kinase kinase activity; metal ion binding; PDZ domain binding; protein binding; protein serine/threonine kinase activator activity; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity; scaffold protein binding
Biological Process:  activation of MAPK activity; ERK1 and ERK2 cascade; MAPK cascade; negative regulation of gene expression; peptidyl-serine autophosphorylation; peptidyl-tyrosine phosphorylation; positive regulation of production of miRNAs involved in gene silencing by miRNA; positive regulation of protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; regulation of early endosome to late endosome transport; regulation of Golgi inheritance; regulation of stress-activated MAPK cascade
Disease: Cardiofaciocutaneous Syndrome 4
Reference #:  P36507 (UniProtKB)
Alt. Names/Synonyms: Dual specificity mitogen-activated protein kinase kinase 2; ERK activator kinase 2; FLJ26075; MAP kinase kinase 2; MAP2K2; MAPK/ERK kinase 2; MAPKK 2; MAPKK2; MEK 2; MEK2; mitogen-activated protein kinase kinase 2; mitogen-activated protein kinase kinase 2, p45; MKK2; MP2K2; PRKMK2
Gene Symbols: MAP2K2
Molecular weight: 44,424 Da
Basal Isoelectric point: 6.12  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Angiogenesis  |  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  GPCR Signaling to MAPKs  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Insulin Receptor Signaling  |  T Cell Receptor Signaling  |  Warburg Effect
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB