BCAR3 a ubiquitously expressed regulator of R-Ras activity that has been implicated in breast cancer. A GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1. Can accelerate the degradation of IRS-1, thus regulating signaling through the insulin receptor. When overexpressed, it confers anti-estrogen resistance in breast cancer cell lines. May also be regulated by cellular adhesion to extracellular matrix proteins. Up-regulated by interleukin-1-alpha and TNF-beta in thymus cortical reticular cell lines (mouse).Two alternatively spliced human isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold; GEF; GEF, Ras; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 3|3 G1
Cellular Component: 
Molecular Function:  guanyl-nucleotide exchange factor activity
Biological Process:  lens morphogenesis in camera-type eye; positive regulation of peptidyl-serine phosphorylation; signal transduction; small GTPase mediated signal transduction
Reference #:  Q9QZK2 (UniProtKB)
Alt. Names/Synonyms: AI131758; AND-34; And34; Bcar3; breast cancer anti-estrogen resistance 3; Breast cancer anti-estrogen resistance protein 3; p130Cas-binding protein AND-34
Gene Symbols: Bcar3
Molecular weight: 92,263 Da
Basal Isoelectric point: 7.88  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene