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Caldesmon iso5
Actin- and myosin-binding protein implicated in the regulation of actomyosin interactions in smooth muscle and nonmuscle cells (could act as a bridge between myosin and actin filaments). Stimulates actin binding of tropomyosin which increases the stabilization of actin filament structure. In muscle tissues, inhibits the actomyosin ATPase by binding to F-actin. This inhibition is attenuated by calcium-calmodulin and is potentiated by tropomyosin. Interacts with actin, myosin, two molecules of tropomyosin and with calmodulin. Also play an essential role during cellular mitosis and receptor capping. Involved in Schwann cell migration during peripheral nerve regeneration. Belongs to the caldesmon family. High-molecular-weight caldesmon (isoform 1) is predominantly expressed in smooth muscles, whereas low-molecular-weight caldesmon (isoforms 2, 3, 4 and 5) are widely distributed in non-muscle tissues and cells. Not expressed in skeletal muscle or heart. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Actin-binding |
| Chromosomal Location of mouse Ortholog: 6 B1|6 15.07 cM |
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Cellular Component:
actin cap; actin cytoskeleton; actin filament; dendrite; dendritic spine; glutamatergic synapse; membrane; neuronal cell body; plasma membrane; postsynapse
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Molecular Function:
actin binding; myosin binding
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Biological Process:
actin filament bundle assembly; angiogenesis; positive regulation of protein binding; regulation of smooth muscle contraction; response to transforming growth factor beta
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Reference #:
Q8VCQ8
(UniProtKB)
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Alt. Names/Synonyms: 4833423D12Rik; AI195384; AV071549; AW536160; C920027I18Rik; Cald1; caldesmon; Caldesmon 1; Caldesmon iso5; MGC30319; OTTMUSP00000015674
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Gene Symbols: Cald1
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Molecular weight:
60,453 Da
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Basal Isoelectric point:
6.98
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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