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DSC2
Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Expressed in epithelia, myocardium and lymph nodes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Cell adhesion; Membrane protein, integral |
| Chromosomal Location of human Ortholog: 18q12.1 |
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Cellular Component:
cell-cell adherens junction; cornified envelope; cytoplasmic vesicle; desmosome; integral component of membrane; intercalated disc; plasma membrane
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Molecular Function:
calcium ion binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein binding
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Biological Process:
bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cardiac muscle cell-cardiac muscle cell adhesion; cell adhesion; cellular response to starvation; cornification; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
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Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
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Reference #:
Q02487
(UniProtKB)
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Alt. Names/Synonyms: ARVD11; Cadherin family member 2; CDHF2; desmocollin 2; Desmocollin-2; Desmocollin-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DKFZp686I11137; DSC2; DSC3
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Gene Symbols: DSC2
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Molecular weight:
99,962 Da
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Basal Isoelectric point:
5.19
Predict pI for various phosphorylation states
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