DSC2 Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Expressed in epithelia, myocardium and lymph nodes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Membrane protein, integral
Chromosomal Location of human Ortholog: 18q12.1
Cellular Component:  cell-cell adherens junction; cornified envelope; cytoplasmic vesicle; desmosome; integral component of membrane; intercalated disc; plasma membrane
Molecular Function:  calcium ion binding; cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication; protein binding
Biological Process:  bundle of His cell-Purkinje myocyte adhesion involved in cell communication; cardiac muscle cell-cardiac muscle cell adhesion; cell adhesion; cellular response to starvation; cornification; homophilic cell adhesion via plasma membrane adhesion molecules; keratinization; regulation of heart rate by cardiac conduction; regulation of ventricular cardiac muscle cell action potential
Disease: Arrhythmogenic Right Ventricular Dysplasia, Familial, 11
Reference #:  Q02487 (UniProtKB)
Alt. Names/Synonyms: ARVD11; Cadherin family member 2; CDHF2; desmocollin 2; Desmocollin-2; Desmocollin-3; Desmosomal glycoprotein II; desmosomal glycoprotein II/III; Desmosomal glycoprotein III; DG2; DGII/III; DKFZp686I11137; DSC2; DSC3
Gene Symbols: DSC2
Molecular weight: 99,962 Da
Basal Isoelectric point: 5.19  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein