MAPKAPK5 a member of the MAPKAPK family of protein kinases. Activated through phosphorylation by MAP kinases including ERK, p38-alpha, and MAPp38-beta In response to cellular stress and proinflammatory cytokines. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; MAPKAPK family; MAPKAPK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor
Chromosomal Location of Human Ortholog: 5|5 F
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  calcium-dependent protein serine/threonine kinase activity; calmodulin binding; calmodulin-dependent protein kinase activity; p53 binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  cell surface receptor signaling pathway; MAPK cascade; peptidyl-serine phosphorylation; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; Ras protein signal transduction; regulation of translation; stress-induced premature senescence
Reference #:  O54992 (UniProtKB)
Alt. Names/Synonyms: MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPK5; MAPKAP kinase 5; MAPKAPK-5; Mapkapk5; MK5; OTTMUSP00000027532; PRAK
Gene Symbols: Mapkapk5
Molecular weight: 54,152 Da
Basal Isoelectric point: 7.29  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics  |  Regulation of P38 MAPKs
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MAPKAPK5

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene