GSTP1 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. Belongs to the GST superfamily. Pi family. Note: This description may include information from UniProtKB.

Protein type: EC 2.5.1.18; Other Amino Acids Metabolism - glutathione; Transferase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of human Ortholog: 11q13.2

Cellular Component: cytoplasm; cytosol; extracellular region; ficolin-1-rich granule lumen; mitochondrion; nucleus; secretory granule lumen; TRAF2-GSTP1 complex

Molecular Function: dinitrosyl-iron complex binding; fatty acid binding; glutathione peroxidase activity; glutathione transferase activity; JUN kinase binding; kinase regulator activity; nitric oxide binding; protein binding; S-nitrosoglutathione binding

Biological Process: cellular oxidant detoxification; cellular response to lipopolysaccharide; central nervous system development; common myeloid progenitor cell proliferation; glutathione derivative biosynthetic process; glutathione metabolic process; hepoxilin biosynthetic process; linoleic acid metabolic process; negative regulation of acute inflammatory response; negative regulation of apoptotic process; negative regulation of biosynthetic process; negative regulation of ERK1 and ERK2 cascade; negative regulation of extrinsic apoptotic signaling pathway; negative regulation of fibroblast proliferation; negative regulation of I-kappaB kinase/NF-kappaB signaling; negative regulation of interleukin-1 beta production; negative regulation of JUN kinase activity; negative regulation of leukocyte proliferation; negative regulation of MAP kinase activity; negative regulation of MAPK cascade; negative regulation of monocyte chemotactic protein-1 production; negative regulation of nitric-oxide synthase biosynthetic process; negative regulation of protein kinase activity; negative regulation of stress-activated MAPK cascade; negative regulation of tumor necrosis factor production; negative regulation of tumor necrosis factor-mediated signaling pathway; nitric oxide storage; positive regulation of superoxide anion generation; prostaglandin metabolic process; regulation of ERK1 and ERK2 cascade; regulation of stress-activated MAPK cascade; response to reactive oxygen species; xenobiotic metabolic process

Reference #: P09211 (UniProtKB)

Alt. Names/Synonyms: deafness, X-linked 7; DFN7; epididymis secretory protein Li 22; FAEES3; fatty acid ethyl ester synthase III; Glutathione S-transferase P; glutathione S-transferase pi 1; GST class-pi; GST3; GSTP; GSTP1; GSTP1-1; HEL-S-22; PI

Gene Symbols: GSTP1

Molecular weight: 23,356 Da

Basal Isoelectric point: 5.43 Predict pI for various phosphorylation states

Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology^®

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GSTP1

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