SSB1 Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. Belongs to the SPSB family. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of human Ortholog: 1p36.22
Cellular Component:  cytosol
Molecular Function:  protein binding; protein binding, bridging involved in substrate recognition for ubiquitination
Biological Process:  post-translational protein modification; protein polyubiquitination; protein ubiquitination; ubiquitin-dependent protein catabolic process
Reference #:  Q96BD6 (UniProtKB)
Alt. Names/Synonyms: novel SPRY domain containing protein; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1; SPSB1; SSB-1; SSB1
Gene Symbols: SPSB1
Molecular weight: 30,942 Da
Basal Isoelectric point: 8.34  Predict pI for various phosphorylation states
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SSB1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene