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SSB1
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2. Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5. Belongs to the SPSB family. Note: This description may include information from UniProtKB.
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| Protein type: Adaptor/scaffold; Ubiquitin conjugating system |
| Chromosomal Location of human Ortholog: 1p36.22 |
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Cellular Component:
cytosol; SCF ubiquitin ligase complex
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Molecular Function:
protein binding; ubiquitin ligase-substrate adaptor activity
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Biological Process:
proteasome-mediated ubiquitin-dependent protein catabolic process; protein ubiquitination; ubiquitin-dependent protein catabolic process
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Reference #:
Q96BD6
(UniProtKB)
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Alt. Names/Synonyms: novel SPRY domain containing protein; splA/ryanodine receptor domain and SOCS box containing 1; SPRY domain-containing SOCS box protein 1; SPRY domain-containing SOCS box protein SSB-1; SPSB1; SSB-1; SSB1
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Gene Symbols: SPSB1
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Molecular weight:
30,942 Da
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Basal Isoelectric point:
8.34
Predict pI for various phosphorylation states
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