ZNF326 Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. May play a role in neuronal differentiation and is able to bind DNA and activate expression in vitro. Belongs to the AKAP95 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Transcription factor
Chromosomal Location of Human Ortholog: 5|5 E5
Cellular Component:  DBIRD complex; intracellular membrane-bounded organelle; nuclear matrix; nucleoplasm; nucleus
Molecular Function:  DNA binding; metal ion binding; RNA polymerase II complex binding; zinc ion binding
Biological Process:  mRNA processing; positive regulation of transcription, DNA-templated; regulation of DNA-templated transcription, elongation; regulation of RNA splicing; RNA splicing
Reference #:  O88291 (UniProtKB)
Alt. Names/Synonyms: 5730470H14Rik; DBIRD complex subunit ZNF326; OTTMUSP00000027418; ZAN; Zan75; Zfp326; Zinc finger protein 326; Zinc finger protein interacting with mRNPs; Zinc finger protein-associated with nuclear matrix of 75 kDa; Zird; ZN326; Znf326
Gene Symbols: Znf326
Molecular weight: 65,225 Da
Basal Isoelectric point: 5.09  Predict pI for various phosphorylation states
Select Structure to View Below

ZNF326

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene