TMEM106B Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with MAP6. May act by inhibiting retrograde transport of lysosomes along dendrites. Required for dendrite branching. Belongs to the TMEM106 family. Expressed in frontal cortex. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 7p21.3
Cellular Component:  endosome; integral component of membrane; late endosome membrane; lysosomal membrane; lysosome
Molecular Function:  protein binding
Biological Process:  dendrite morphogenesis; lysosome localization; positive regulation of dendrite development
Disease: Leukodystrophy, Hypomyelinating, 16
Reference #:  Q9NUM4 (UniProtKB)
Alt. Names/Synonyms: FLJ11273; HLD16; MGC33727; T106B; TMEM106B; TMEM106B protein; Transmembrane protein 106B
Gene Symbols: TMEM106B
Molecular weight: 31,127 Da
Basal Isoelectric point: 6.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein