MED25 Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. Belongs to the Mediator complex subunit 25 family. Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Transcription, coactivator/corepressor
Chromosomal Location of human Ortholog: 19q13.33
Cellular Component:  nucleoplasm
Molecular Function:  protein binding; retinoic acid receptor binding; retinoid X receptor binding; transcription factor binding
Biological Process:  negative regulation of fibroblast proliferation; negative regulation of transcription by RNA polymerase II; positive regulation of cell cycle arrest; positive regulation of chromatin binding; positive regulation of mediator complex assembly; positive regulation of transcription by RNA polymerase II; transcription initiation from RNA polymerase II promoter
Disease: Basel-vanagaite-smirin-yosef Syndrome; Charcot-marie-tooth Disease, Axonal, Type 2b2
Reference #:  Q71SY5 (UniProtKB)
Alt. Names/Synonyms: ACID1; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC92; BVSYS; CMT2B2; DKFZp434K0512; MED25; Mediator complex subunit 25; Mediator of RNA polymerase II transcription subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog; MGC70671; p78; prostate-derived protein 78 kDa; PTOV2; TCBAP0758
Gene Symbols: MED25
Molecular weight: 78,171 Da
Basal Isoelectric point: 8.61  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene