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MED25
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription. Belongs to the Mediator complex subunit 25 family. Ubiquitously expressed. Highest levels in brain, heart, kidney, peripheral leukocytes, placenta, skeletal muscle and spleen. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Transcription, coactivator/corepressor |
| Chromosomal Location of human Ortholog: 19q13.33 |
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Cellular Component:
core mediator complex; mediator complex; nucleoplasm; nucleus; transcription regulator complex
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Molecular Function:
nuclear retinoic acid receptor binding; nuclear retinoid X receptor binding; protein binding; transcription coactivator binding
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Biological Process:
negative regulation of fibroblast proliferation; negative regulation of transcription by RNA polymerase II; positive regulation of chromatin binding; positive regulation of mediator complex assembly; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; positive regulation of transcription initiation by RNA polymerase II; RNA polymerase II preinitiation complex assembly
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Disease: Basel-vanagaite-smirin-yosef Syndrome; Charcot-marie-tooth Disease, Axonal, Type 2b2
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Reference #:
Q71SY5
(UniProtKB)
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Alt. Names/Synonyms: ACID1; Activator interaction domain-containing protein 1; Activator-recruited cofactor 92 kDa component; ARC/mediator transcriptional coactivator subunit; ARC92; BVSYS; CMT2B2; DKFZp434K0512; MED25; Mediator complex subunit 25; Mediator of RNA polymerase II transcription subunit 25; mediator of RNA polymerase II transcription, subunit 25 homolog; MGC70671; p78; prostate-derived protein 78 kDa; PTOV2; TCBAP0758
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Gene Symbols: MED25
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Molecular weight:
78,171 Da
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Basal Isoelectric point:
8.61
Predict pI for various phosphorylation states
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