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FAM83H
May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. Expressed in the tooth follicle. Note: This description may include information from UniProtKB.
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| Protein type: Unknown function |
| Chromosomal Location of human Ortholog: 8q24.3 |
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Cellular Component:
cytoplasm; keratin filament
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Molecular Function:
keratin filament binding; protein binding; protein kinase binding
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Biological Process:
biomineral tissue development; intermediate filament cytoskeleton organization; positive regulation of cell migration; protein localization to cytoskeleton; signal transduction
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Disease: Amelogenesis Imperfecta, Type Iii
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Reference #:
Q6ZRV2
(UniProtKB)
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Alt. Names/Synonyms: AI3; AI3A; FA83H; FAM83H; FAM83H variant 1; FAM83H variant 2; family with sequence similarity 83 member H; family with sequence similarity 83, member H; FLJ46072; Protein FAM83H; truncated FAM83H
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Gene Symbols: FAM83H
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Molecular weight:
127,122 Da
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Basal Isoelectric point:
6.52
Predict pI for various phosphorylation states
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