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PIK3C3
Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. Belongs to the PI3/PI4-kinase family. Ubiquitously expressed, with a highest expression in skeletal muscle. Note: This description may include information from UniProtKB.
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| Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC 2.7.1.137; Kinase, lipid; Kinase, protein; Motility/polarity/chemotaxis |
| Chromosomal Location of mouse Ortholog: 18|18 B1 |
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Cellular Component:
autolysosome; cytoplasm; cytoplasmic vesicle; endosome; late endosome; membrane; midbody; peroxisome; phagocytic vesicle; phagophore assembly site; phosphatidylinositol 3-kinase complex, class III; phosphatidylinositol 3-kinase complex, class III, type I; phosphatidylinositol 3-kinase complex, class III, type II
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Molecular Function:
1-phosphatidylinositol-3-kinase activity; ATP binding; kinase activity; nucleotide binding; phosphatidylinositol kinase activity; protein binding; protein kinase activity; transferase activity
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Biological Process:
autophagosome assembly; autophagosome maturation; autophagy; autophagy of peroxisome; cell cycle; cell division; cellular response to glucose starvation; cellular response to starvation; early endosome to late endosome transport; endocytosis; endosome organization; lipid metabolic process; macroautophagy; phosphatidylinositol phosphate biosynthetic process; phosphatidylinositol-3-phosphate biosynthetic process; phosphatidylinositol-mediated signaling; phosphorylation; positive regulation by host of viral genome replication; protein lipidation; protein localization to phagophore assembly site; protein phosphorylation; protein processing; protein targeting to lysosome; regulation of autophagy; regulation of cytokinesis; regulation of macroautophagy; selective autophagy
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Reference #:
Q6PF93
(UniProtKB)
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Alt. Names/Synonyms: 5330434F23Rik; OTTMUSP00000023341; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3-kinase type 3; PI3K type 3; Pik3c3; PK3C3; PtdIns-3-kinase type 3; Vps34
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Gene Symbols: Pik3c3
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Molecular weight:
101,487 Da
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Basal Isoelectric point:
6.28
Predict pI for various phosphorylation states
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CST Pathways:
Actin Dynamics
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Adherens Junction Dynamics
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AMPK Signaling
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Angiogenesis
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Apoptosis Regulation
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Autophagy Signaling
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ErbB/HER Signaling
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ESC Pluripotency and Differentiation
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Growth And Differentiation Control by MAPKs
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IL6 Signaling
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Inhibition of Apoptosis
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Microtubule Dynamics
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Mitochondrial Control of Apoptosis
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mTOR Signaling
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NF-kB Signaling
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PI3K/Akt Signaling
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Protein Kinase C Signaling
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SAPK/JNK Signaling Cascades
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T Cell Receptor Signaling
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TGF-ß Signaling
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Translation: eIF4E and p70S6K
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Warburg Effect
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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