PIK3C3 Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. Belongs to the PI3/PI4-kinase family. Ubiquitously expressed, with a highest expression in skeletal muscle. Note: This description may include information from UniProtKB.
Protein type: Autophagy; Carbohydrate Metabolism - inositol phosphate; EC; Kinase, lipid; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 18q12.3
Cellular Component:  autolysosome; axoneme; cytosol; late endosome; midbody; phagocytic vesicle membrane; phosphatidylinositol 3-kinase complex, class III
Molecular Function:  1-phosphatidylinositol-3-kinase activity; ATP binding; kinase activity; protein binding; protein kinase activity
Biological Process:  autophagy; cell cycle; cell division; cellular response to glucose starvation; early endosome to late endosome transport; endosome organization; macroautophagy; phosphatidylinositol biosynthetic process; protein lipidation; protein localization to phagophore assembly site; protein processing; regulation of cytokinesis; regulation of protein secretion; response to leucine; toll-like receptor 9 signaling pathway
Reference #:  Q8NEB9 (UniProtKB)
Alt. Names/Synonyms: hVps34; MGC61518; Phosphatidylinositol 3-kinase catalytic subunit type 3; Phosphatidylinositol 3-kinase p100 subunit; Phosphoinositide-3-kinase class 3; phosphoinositide-3-kinase, class 3; PI3-kinase type 3; PI3K type 3; PIK3C3; PK3C3; PtdIns-3-kinase type 3; VPS34
Gene Symbols: PIK3C3
Molecular weight: 101,549 Da
Basal Isoelectric point: 6.37  Predict pI for various phosphorylation states
CST Pathways:  Actin Dynamics  |  Adherens Junction Dynamics  |  AMPK Signaling  |  Angiogenesis  |  Apoptosis Regulation  |  Autophagy Signaling  |  ErbB/HER Signaling  |  ESC Pluripotency and Differentiation  |  Growth And Differentiation Control by MAPKs  |  IL6 Signaling  |  Inhibition of Apoptosis  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  mTOR Signaling  |  NF-kB Signaling  |  PI3K/Akt Signaling  |  Protein Kinase C Signaling  |  SAPK/JNK Signaling Cascades  |  T Cell Receptor Signaling  |  TGF-ß Signaling  |  Translation: eIF4E and p70S6K  |  Warburg Effect
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein