PHIP Probable regulator of the insulin and insulin-like growth factor signaling pathways. Stimulates cell proliferation through regulation of cyclin transcription and has an anti-apoptotic activity through AKT1 phosphorylation and activation. Plays a role in the regulation of cell morphology and cytoskeletal organization. Expressed in myeloma and epidermoid carcinoma cell lines. Note: This description may include information from UniProtKB.
Chromosomal Location of human Ortholog: 6q14.1
Cellular Component:  nucleus
Molecular Function:  insulin receptor binding; lysine-acetylated histone binding; protein binding
Biological Process:  cytoskeleton organization; insulin receptor signaling pathway; negative regulation of apoptotic process; negative regulation of extrinsic apoptotic signaling pathway; positive regulation of cell population proliferation; positive regulation of DNA-templated transcription; positive regulation of insulin-like growth factor receptor signaling pathway; positive regulation of mitotic nuclear division; positive regulation of transcription by RNA polymerase II; regulation of cell morphogenesis; regulation of cell shape; regulation of protein phosphorylation; regulation of transcription by RNA polymerase II
Disease: Developmental Delay, Intellectual Disability, Obesity, And Dysmorphic Features
Reference #:  Q8WWQ0 (UniProtKB)
Alt. Names/Synonyms: BRWD2; CHUJANS; DCAF14; DDB1 and CUL4 associated factor 14; DDB1- and CUL4-associated factor 14; DIDOD; FLJ20705; FLJ45918; IRS-1 PH domain-binding protein; MGC90216; ndrp; PH-interacting protein; PHIP; pleckstrin homology domain interacting protein; WD repeat-containing protein 11; WDDR11; WDR11
Gene Symbols: PHIP
Molecular weight: 206,689 Da
Basal Isoelectric point: 9.02  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein