FBX43 Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable). Part of a SCF (SKP1-cullin-F-box) protein ligase complex. May interact with CDC20. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 8q22.2
Cellular Component: 
Molecular Function:  metal ion binding
Biological Process:  meiotic cell cycle; protein ubiquitination
Reference #:  Q4G163 (UniProtKB)
Alt. Names/Synonyms: early mitotic inhibitor 2; EMI2; Endogenous meiotic inhibitor 2; ERP1; F-box only protein 43; F-box protein 43; Fbx43; FBXO43
Gene Symbols: FBXO43
Molecular weight: 78,402 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
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FBX43

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene