FBX43 Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of human Ortholog: 8q22.2
Cellular Component:  nucleus
Molecular Function:  metal ion binding; protein binding
Biological Process:  meiotic cell cycle; negative regulation of cell cycle process; negative regulation of meiotic nuclear division; protein ubiquitination; regulation of mitotic nuclear division
Disease: Oocyte Maturation Defect 12; Spermatogenic Failure 64
Reference #:  Q4G163 (UniProtKB)
Alt. Names/Synonyms: early mitotic inhibitor 2; EMI2; Endogenous meiotic inhibitor 2; ERP1; F-box only protein 43; F-box protein 43; Fbx43; FBXO43
Gene Symbols: FBXO43
Molecular weight: 78,402 Da
Basal Isoelectric point: 8.4  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene