FBX43
Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Note: This description may include information from UniProtKB.
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Protein type: Unknown function |
Chromosomal Location of human Ortholog: 8q22.2 |
Cellular Component:
nucleus
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Molecular Function:
protein binding; zinc ion binding
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Biological Process:
meiotic cell cycle; negative regulation of cell cycle process; negative regulation of meiotic nuclear division; protein ubiquitination; regulation of mitotic nuclear division
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Disease: Oocyte Maturation Defect 12; Spermatogenic Failure 64
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Reference #:
Q4G163
(UniProtKB)
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Alt. Names/Synonyms: early mitotic inhibitor 2; EMI2; Endogenous meiotic inhibitor 2; ERP1; F-box only protein 43; F-box protein 43; Fbx43; FBXO43
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Gene Symbols: FBXO43
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Molecular weight:
78,402 Da
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Basal Isoelectric point:
8.4
Predict pI for various phosphorylation states
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