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HEPACAM2
Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Membrane protein, integral |
| Chromosomal Location of Human Ortholog: 7q21.2 |
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Cellular Component:
centrosome; Golgi apparatus; Golgi membrane; integral component of membrane; midbody; spindle
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Molecular Function:
protein binding
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Biological Process:
cell division; centrosome cycle
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Reference #:
A8MVW5
(UniProtKB)
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Alt. Names/Synonyms: HECA2; HEPACAM family member 2; HEPACAM2; MIKI; Mitotic kinetics regulator
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Gene Symbols: HEPACAM2
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Molecular weight:
51,407 Da
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Basal Isoelectric point:
6.09
Predict pI for various phosphorylation states
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