HEPACAM2 Required during prometaphase for centrosome maturation. Following poly-ADP-ribosylation (PARsylation) by TNKS, translocates from the Golgi apparatus to mitotic centrosomes and plays a key role in the formation of robust microtubules for prompt movement of chromosomes: anchors AKAP9/CG-NAP, a scaffold protein of the gamma-tubulin ring complex and promotes centrosome maturation. Widely expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of human Ortholog: 7q21.2
Cellular Component:  centrosome; Golgi apparatus; Golgi membrane; intracellular membrane-bounded organelle; midbody; mitotic spindle; nucleoplasm; spindle
Molecular Function:  protein binding
Biological Process:  cell division; centrosome cycle
Reference #:  A8MVW5 (UniProtKB)
Alt. Names/Synonyms: HECA2; HEPACAM family member 2; HEPACAM2; MIKI; Mitotic kinetics regulator
Gene Symbols: HEPACAM2
Molecular weight: 51,407 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein