EPHX2 Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Hydrolase; Lipid Metabolism - arachidonic acid
Chromosomal Location of Human Ortholog: 14 D1|14 34.36 cM
Cellular Component:  cytoplasm; cytosol; peroxisome
Molecular Function:  10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity; catalytic activity; epoxide hydrolase activity; hydrolase activity; lipid phosphatase activity; magnesium ion binding; metal ion binding; phosphatase activity; protein homodimerization activity; signaling receptor binding; toxic substance binding
Biological Process:  aromatic compound catabolic process; cholesterol homeostasis; dephosphorylation; epoxide metabolic process; inflammatory response; linoleic acid metabolic process; lipid metabolic process; metabolic process; phospholipid dephosphorylation; positive regulation of blood pressure; positive regulation of gene expression; prostaglandin production involved in inflammatory response; regulation of cholesterol metabolic process; response to toxic substance; sensory perception of pain; stilbene catabolic process
Reference #:  P34914 (UniProtKB)
Alt. Names/Synonyms: AW106936; Bifunctional epoxide hydrolase 2; CEH; Cytosolic epoxide hydrolase; Cytosolic epoxide hydrolase 2; Eph; Eph2; Ephx2; Epoxide hydratase; Epoxide hydrolase 2; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2C; HYES; Lipid-phosphate phosphatase; SEH; sEP; Soluble epoxide hydrolase
Gene Symbols: Ephx2
Molecular weight: 62,515 Da
Basal Isoelectric point: 5.85  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene