EPHX2 Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Belongs to the AB hydrolase superfamily. Epoxide hydrolase family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.1.3.76; EC 3.3.2.10; Hydrolase; Lipid Metabolism - arachidonic acid
Chromosomal Location of human Ortholog: 8p21.2-p21.1
Cellular Component:  cytosol; peroxisomal matrix; peroxisome
Molecular Function:  10-hydroxy-9-(phosphonooxy)octadecanoate phosphatase activity; epoxide hydrolase activity; hydrolase activity; lipid phosphatase activity; lysophosphatidic acid phosphatase activity; magnesium ion binding; phosphatase activity; protein homodimerization activity; toxic substance binding
Biological Process:  cholesterol homeostasis; dephosphorylation; epoxide metabolic process; phospholipid dephosphorylation; positive regulation of gene expression; regulation of cholesterol metabolic process; response to toxic substance; stilbene catabolic process
Disease: Hypercholesterolemia, Familial
Reference #:  P34913 (UniProtKB)
Alt. Names/Synonyms: ABHD20; Bifunctional epoxide hydrolase 2; CEH; Cytosolic epoxide hydrolase; Cytosolic epoxide hydrolase 2; EPHX2; Epoxide hydratase; Epoxide hydrolase 2; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble; HYES; Lipid-phosphate phosphatase; SEH; Soluble epoxide hydrolase
Gene Symbols: EPHX2
Molecular weight: 62,616 Da
Basal Isoelectric point: 5.91  Predict pI for various phosphorylation states
Select Structure to View Below

EPHX2

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB