SLC25A1 Citrate transporter that mediates the exchange of mitochondrial citrate for cytosolic malate. Also able to mediate the exchange of citrate for isocitrate, phosphoenolpyruvate, cis- but not trans-aconitate and to a lesser extend maleate and succinate. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD(+) for the glycolytic pathway. Required for proper neuromuscular junction formation. Belongs to the mitochondrial carrier (TC 2.A.29) family. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass; Mitochondrial; Transporter; Transporter, SLC family
Chromosomal Location of Human Ortholog: 22q11.21
Cellular Component:  integral component of membrane; mitochondrial inner membrane
Molecular Function:  citrate secondary active transmembrane transporter activity; citrate transmembrane transporter activity; tricarboxylic acid transmembrane transporter activity
Biological Process:  fatty-acyl-CoA biosynthetic process; gluconeogenesis
Disease: Combined D-2- And L-2-hydroxyglutaric Aciduria; Myasthenic Syndrome, Congenital, 23, Presynaptic
Reference #:  P53007 (UniProtKB)
Alt. Names/Synonyms: Citrate transport protein; citrate transporter), member 1; CTP; SLC20A3; SLC25A1; solute carrier family 20 (mitochondrial citrate transporter), member 3; solute carrier family 25 (mitochondrial carrier; Solute carrier family 25 member 1; Tricarboxylate carrier protein; Tricarboxylate transport protein, mitochondrial; TXTP
Gene Symbols: SLC25A1
Molecular weight: 34,013 Da
Basal Isoelectric point: 9.91  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB