ERK4 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. High expression in heart and brain. Note: This description may include information from UniProtKB.

Protein type: CMGC group; EC 2.7.11.24; ERK3 subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)

Chromosomal Location of human Ortholog: 18q21.1-q21.2

Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus

Molecular Function: ATP binding; MAP kinase activity; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein serine kinase activity; protein serine/threonine kinase activity

Biological Process: cell cycle; intracellular signal transduction; MAPK cascade; protein phosphorylation

Reference #: P31152 (UniProtKB)

Alt. Names/Synonyms: ERK-4; ERK3; Erk3-related; ERK4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MAPK4; Mitogen-activated protein kinase 4; MK04; p63-MAPK; p63MAPK; PRKM4

Gene Symbols: MAPK4

Molecular weight: 65,922 Da

Basal Isoelectric point: 5.25 Predict pI for various phosphorylation states

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ERK4