ERK4 Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK4/MAPK4 is phosphorylated at Ser-186 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK4/MAPK4. May promote entry in the cell cycle. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. High expression in heart and brain. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; ERK subfamily; Kinase, protein; MAPK family; MAPK/ERK subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 18q21.1-q21.2
Cellular Component:  cytoplasm; cytosol; nucleoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein heterodimerization activity; protein homodimerization activity; protein kinase binding; protein serine/threonine kinase activity
Biological Process:  cell cycle; MAPK cascade; protein phosphorylation
Reference #:  P31152 (UniProtKB)
Alt. Names/Synonyms: ERK-4; ERK3; Erk3-related; ERK4; Extracellular signal-regulated kinase 4; MAP kinase 4; MAP kinase isoform p63; MAPK 4; MAPK4; Mitogen-activated protein kinase 4; MK04; p63-MAPK; p63MAPK; PRKM4
Gene Symbols: MAPK4
Molecular weight: 65,922 Da
Basal Isoelectric point: 5.25  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
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ERK4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB