plakophilin 1 Seems to play a role in junctional plaques. Contributes to epidermal morphogenesis. Belongs to the beta-catenin family. Isoform 2 is widely expressed. Isoform 1 is expressed in stratified squamous, complex, glandular duct and bladder epithelia. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell adhesion; Motility/polarity/chemotaxis
Chromosomal Location of mouse Ortholog: 1|1 E4
Cellular Component:  cell junction; cell-cell adherens junction; cell-cell junction; cytoplasm; desmosome; intracellular membrane-bounded organelle; messenger ribonucleoprotein complex; nucleoplasm; nucleus; plasma membrane
Molecular Function:  cadherin binding; lamin binding; protein binding
Biological Process:  cell adhesion; cell-cell adhesion; cell-cell junction assembly; intermediate filament bundle assembly; negative regulation of mRNA catabolic process; positive regulation of gene expression
Reference #:  P97350 (UniProtKB)
Alt. Names/Synonyms: AI528551; OTTMUSP00000025630; Pkp1; plakophilin 1; Plakophilin-1
Gene Symbols: Pkp1
Molecular weight: 80,896 Da
Basal Isoelectric point: 9.15  Predict pI for various phosphorylation states
Select Structure to View Below

plakophilin 1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene