BCDO2 Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects. Belongs to the carotenoid oxygenase family. Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level). 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase
Chromosomal Location of Human Ortholog: 9|9 A5.3
Cellular Component:  mitochondrion
Molecular Function:  beta,beta-carotene-9',10'-cleaving oxygenase activity; beta-carotene 15,15'-monooxygenase activity; carotenoid dioxygenase activity; dioxygenase activity; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; retinal isomerase activity
Biological Process:  carotene catabolic process; carotene metabolic process; carotenoid metabolic process; oxidation-reduction process; regulation of mitochondrial membrane potential; regulation of reactive oxygen species metabolic process; retinal metabolic process; retinoic acid metabolic process; xanthophyll metabolic process
Reference #:  Q99NF1 (UniProtKB)
Alt. Names/Synonyms: b,b-carotene-9',10'-dioxygenase; B-dio; B-diox-II; Bcdo; Bcdo2; Bcmo; Bcmo2; Bco2; Beta,beta-carotene 9',10'-oxygenase; beta-carotene 9', 10'-dioxygenase 2; beta-carotene 9',10'-dioxygenase 2; Beta-carotene dioxygenase 2; beta-carotene oxygenase 2; beta-diox-II; CMO; CMO2; MGC129322; MGC129323
Gene Symbols: Bco2
Molecular weight: 60,142 Da
Basal Isoelectric point: 6.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene