SMS2 Sphingomyelin synthases synthesize the sphingolipid, sphingomyelin, through transfer of the phosphatidyl head group, phosphatidylcholine, on to the primary hydroxyl of ceramide. The reaction is bidirectional depending on the respective levels of the sphingolipid and ceramide. Plasma membrane SMS2 can also convert phosphatidylethanolamine (PE) to ceramide phosphatidylethanolamine (CPE). Major form in liver. Required for cell growth in certain cell types. Regulator of cell surface levels of ceramide, an important mediator of signal transduction and apoptosis. Regulation of sphingomyelin (SM) levels at the cell surface affects insulin sensitivity. Belongs to the sphingomyelin synthase family. Brain, heart, kidney, liver, muscle and stomach. Also expressed in a number of cell lines such as carcinoma HeLa cells, hepatoma Hep-G2 cells, and colon carcinoma Caco-2 cells. Note: This description may include information from UniProtKB.
Protein type: EC; Lipid Metabolism - sphingolipid; Membrane protein, integral; Membrane protein, multi-pass; Transferase
Chromosomal Location of Human Ortholog: 4q25
Cellular Component:  Golgi apparatus; integral component of Golgi membrane; integral component of plasma membrane; plasma membrane
Molecular Function:  ceramide cholinephosphotransferase activity; ceramide phosphoethanolamine synthase activity; kinase activity; sphingomyelin synthase activity
Biological Process:  ceramide phosphoethanolamine biosynthetic process; phosphorylation; sphingolipid biosynthetic process; sphingomyelin biosynthetic process
Disease: Calvarial Doughnut Lesions With Bone Fragility
Reference #:  Q8NHU3 (UniProtKB)
Alt. Names/Synonyms: CDL; MGC26963; Phosphatidylcholine:ceramide cholinephosphotransferase 2; SGMS2; SM synthase; SMS2; Sphingomyelin synthase 2
Gene Symbols: SGMS2
Molecular weight: 42,280 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein