kindlin-2
Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Belongs to the kindlin family. Ubiquitous. Found in numerous tumor tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Cytoskeletal; Motility/polarity/chemotaxis |
Chromosomal Location of mouse Ortholog: 14|14 C1 |
Cellular Component:
adherens junction; anchoring junction; cell junction; cell projection; cytoplasm; cytoplasmic side of plasma membrane; cytoskeleton; cytosol; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; membrane; nucleoplasm; nucleus; plasma membrane; stress fiber
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Molecular Function:
actin binding; actin filament binding; integrin binding; lipid binding; phosphatidylinositol-3,4,5-trisphosphate binding; protein kinase binding; SMAD binding; type I transforming growth factor beta receptor binding
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Biological Process:
adherens junction maintenance; cell adhesion; cell-matrix adhesion; focal adhesion assembly; integrin activation; integrin-mediated signaling pathway; limb development; negative regulation of fat cell differentiation; negative regulation of vascular permeability; positive regulation of cell migration; positive regulation of epithelial to mesenchymal transition; positive regulation of ERK1 and ERK2 cascade; positive regulation of focal adhesion assembly; positive regulation of GTPase activity; positive regulation of integrin activation; positive regulation of mesenchymal stem cell proliferation; positive regulation of myosin light chain kinase activity; positive regulation of osteoblast differentiation; positive regulation of protein kinase B signaling; positive regulation of protein localization to nucleus; positive regulation of stress fiber assembly; positive regulation of substrate adhesion-dependent cell spreading; positive regulation of wound healing, spreading of epidermal cells; protein localization to cell junction; protein localization to membrane; regulation of cell morphogenesis; regulation of cell shape; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway; Wnt signaling pathway
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Reference #:
Q8CIB5
(UniProtKB)
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Alt. Names/Synonyms: AA960555; FERM2; Fermitin family homolog 2; fermitin family homolog 2 (Drosophila); fermitin family member 2; Fermt2; Kind; Kindlin-2; MGC36305; Mig; Mig2; mitogen inducible 2; OTTMUSP00000032080; pleckstrin homology domain containing, family C (with FERM domain) member 1; Pleckstrin homology domain-containing family C member 1; Plekh; Plekhc1
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Gene Symbols: Fermt2
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Molecular weight:
77,800 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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