kindlin-2 Scaffolding protein that enhances integrin activation mediated by TLN1 and/or TLN2, but activates integrins only weakly by itself. Binds to membranes enriched in phosphoinositides. Enhances integrin-mediated cell adhesion onto the extracellular matrix and cell spreading; this requires both its ability to interact with integrins and with phospholipid membranes. Required for the assembly of focal adhesions. Participates in the connection between extracellular matrix adhesion sites and the actin cytoskeleton and also in the orchestration of actin assembly and cell shape modulation. Recruits FBLIM1 to focal adhesions. Plays a role in the TGFB1 and integrin signaling pathways. Stabilizes active CTNNB1 and plays a role in the regulation of transcription mediated by CTNNB1 and TCF7L2/TCF4 and in Wnt signaling. Belongs to the kindlin family. Ubiquitous. Found in numerous tumor tissues. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of Human Ortholog: 14|14 C1
Cellular Component:  cell junction; cell projection; cytoplasm; cytoskeleton; extrinsic component of cytoplasmic side of plasma membrane; focal adhesion; membrane; nucleoplasm; nucleus; plasma membrane
Molecular Function:  actin filament binding; lipid binding; phosphatidylinositol-3,4,5-trisphosphate binding
Biological Process:  cell adhesion; cell-matrix adhesion; focal adhesion assembly; integrin activation; integrin-mediated signaling pathway; protein localization to membrane; regulation of cell shape; substrate adhesion-dependent cell spreading; transforming growth factor beta receptor signaling pathway; Wnt signaling pathway
Reference #:  Q8CIB5 (UniProtKB)
Alt. Names/Synonyms: AA960555; FERM2; Fermitin family homolog 2; fermitin family homolog 2 (Drosophila); fermitin family member 2; Fermt2; Kind; Kindlin-2; MGC36305; Mig; Mig2; mitogen inducible 2; OTTMUSP00000032080; pleckstrin homology domain containing, family C (with FERM domain) member 1; Pleckstrin homology domain-containing family C member 1; Plekh; Plekhc1
Gene Symbols: Fermt2
Molecular weight: 77,800 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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kindlin-2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene