CGN Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier. Belongs to the cingulin family. Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Adaptor/scaffold
Chromosomal Location of Human Ortholog: 1q21.3
Cellular Component:  bicellular tight junction; cell junction; myosin complex; plasma membrane
Molecular Function:  actin binding; motor activity; protein binding
Biological Process:  transforming growth factor beta receptor signaling pathway
Reference #:  Q9P2M7 (UniProtKB)
Alt. Names/Synonyms: CGN; CING; Cingulin; DKFZp779N1112; FLJ39281; KIAA1319
Gene Symbols: CGN
Molecular weight: 136,386 Da
Basal Isoelectric point: 5.46  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene