CDK5RAP2 Potential regulator of CDK5 activity via its interaction with CDK5R1. Negative regulator of centriole disengagement (licensing) which maintains centriole engagement and cohesion. Involved in regulation of mitotic spindle orientation. Plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, may promote microtubule polymerization, bundle formation, growth and dynamics at the plus ends. Regulates centrosomal maturation by recruitment of the gamma-tubulin ring complex (gamma-TuRC) onto centrosomes. In complex with PDE4DIP isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, contributes to microtubules nucleation and extension from the centrosome to the cell periphery. Required for the recruitment of AKAP9 to centrosomes. Plays a role in neurogenesis. Widely expressed. Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal
Chromosomal Location of Human Ortholog: 9q33.2
Cellular Component:  cell junction; centrosome; cytoplasm; cytoskeleton; cytosol; Golgi apparatus; microtubule; microtubule plus-end; mitotic spindle pole; pericentriolar material; perinuclear region of cytoplasm; spindle pole
Molecular Function:  calmodulin binding; gamma-tubulin binding; microtubule binding; protein binding; protein kinase binding; transcription regulatory region DNA binding; tubulin binding
Biological Process:  brain development; centriole replication; centrosome cycle; chromosome segregation; ciliary basal body-plasma membrane docking; establishment of mitotic spindle orientation; G2/M transition of mitotic cell cycle; microtubule bundle formation; microtubule cytoskeleton organization; microtubule organizing center organization; negative regulation of centriole replication; negative regulation of neuron differentiation; neurogenesis; positive regulation of microtubule polymerization; positive regulation of transcription, DNA-templated; regulation of G2/M transition of mitotic cell cycle; regulation of mitotic cell cycle spindle assembly checkpoint; regulation of neuron differentiation
Disease: Microcephaly 3, Primary, Autosomal Recessive
Reference #:  Q96SN8 (UniProtKB)
Alt. Names/Synonyms: C48; CDK5 activator-binding protein C48; CDK5 regulatory subunit associated protein 2; CDK5 regulatory subunit-associated protein 2; CDK5RAP2; centrosomal protein 215 kDa; Centrosome-associated protein 215; centrosomin; CEP215; CK5P2; DKFZp686B1070; DKFZp686D1070; KIAA1633; MCPH3; microcephaly, primary autosomal recessive 3
Gene Symbols: CDK5RAP2
Molecular weight: 215,038 Da
Basal Isoelectric point: 5.44  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein