NALP10 Inhibits autoprocessing of CASP1, CASP1-dependent IL1B secretion, PYCARD aggregation and PYCARD-mediated apoptosis but not apoptosis induced by FAS or BID. Displays anti-inflammatory activity. Required for immunity against C.albicans infection. Involved in the innate immune response by contributing to proinflammatory cytokine release in response to invasive bacterial infection. Contributes to T-cell-mediated inflammatory responses in the skin. Plays a role in protection against periodontitis through its involvement in induction of IL1A via ERK activation in oral epithelial cells infected with periodontal pathogens. Exhibits both ATPase and GTPase activities. Belongs to the NLRP family. Highly expressed in basal and suprabasal epidermal cell layers with lower levels in dermal fibroblast cells (at protein level) (PubMed:22672233). Widely expressed with highest levels in heart, brain and skeletal muscle (PubMed:15096476). Also expressed in liver, colon, dermis and epidermis (PubMed:15096476). Little expression detected in myeloid cells or peripheral blood mononuclear cells (PubMed:15096476). Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of mouse Ortholog: 7|7 E3
Cellular Component:  cytoplasm; extrinsic component of plasma membrane; membrane; plasma membrane
Molecular Function:  ATP binding; ATPase activity; GTPase activity; nucleotide binding
Biological Process:  adaptive immune response; defense response; defense response to fungus; defense response to Gram-negative bacterium; immune system process; inflammatory response; innate immune response; positive regulation of defense response to bacterium; positive regulation of inflammatory response; positive regulation of interleukin-1 alpha secretion; positive regulation of interleukin-6 secretion; positive regulation of interleukin-8 secretion; positive regulation of T-helper 1 type immune response; positive regulation of T-helper 17 type immune response
Reference #:  Q8CCN1 (UniProtKB)
Alt. Names/Synonyms: 6430548I20Rik; NACHT, leucine rich repeat and PYD containing 10; NACHT, LRR and PYD containing protein 10; NACHT, LRR and PYD domains-containing protein 10; NACHT/LRR/pyrin domain-containing protein 10; NAL10; Nalp10; Napl10; neuronal apoptosis inhibitor protein 10; NLR family, pyrin domain containing 10; Nlrp10; PAN5; Pynod
Gene Symbols: Nlrp10
Molecular weight: 76,367 Da
Basal Isoelectric point: 6.18  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene